Negative regulator of bone growth.Sclerostin (SOST) is a bone morphogenetic protein (BMP) antagonist, leading to the activation of BMP signaling. It negatively regulates the formation of bone by repressing the differentiation and/or function of osteoblasts induced by BMPs. It has been shown that Sclerostin binds BMP-5, -6, and -7 with high affinity and BMP-2 and -4 with low affinity. The noggin-sclerostin protein complex represents a novel mechanism for the fine-tuning of BMP activity in bon
Human,Rat(predicted: Mouse,Dog,Pig,Cow,Horse,Rabbit,Sheep)
WB,IHC-P,IHC-F
Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.